Browsing by Author "Speisky Cosoy, Hernán"
Now showing items 1-20 of 31
-
Speisky Cosoy, Hernán; Squella Serrano, Juan; Núñez Vergara, Luis (1991)Boldine shows a concentration-dependent relaxation effect on the rat ileum preparation with a pD2 of 3.77 ± 0.12. The alkaloid also produces a concentration-dependent parallel shift of the curve-response to acetylcholine, ...
-
Backhouse Erazo, Nadine; Delporte Vergara, Carla; Givernau, M.; Cassels Niven, Bruce; Valenzuela, A.; Speisky Cosoy, Hernán (Birkhäuser Verlag, 1994-03-02)Boldine, an antioxidant alkaloid isolated from Peumus boldus, exhibits a dose-dependent anti-inflammatory activity in the carrageenan-induced guinea pig paw edema test with an oral EDso of 34 mg/kg. Boldine also reduces ...
-
Speisky Cosoy, Hernán; Cassels Niven, Bruce; Lissi Gervaso, Eduardo A.; Videla Cabrera, Luis (1991)Boldine, in low micromolar concentrations, was able to prevent brain homogenate autooxidation, the 2,2'-azobis(2-amidinopropane)(AAP)-induced lipid peroxidation of red cell plasma membranes, and the AAP-induced inactivation ...
-
Speisky Cosoy, Hernán; Cassels Niven, Bruce; Lissi Gervaso, Eduardo A.; Videla Cabrera, Luis (Pergamon Press, 1990-11-30)Boldine, in low micromolar concentrations, was able to prevent brain bomogenate autooxidatíon, the 2,2'·uobis(2·amidinopropane)(AAP)·induced Iipid peroxidation of red cell plasma rnembranes, and the AAP·induced inactivation ...
-
Carrasco Pozo, Catalina; Speisky Cosoy, Hernán; Brunser, Oscar; Pastene, Edgar; Gotteland, Martin (2011)The stability of an apple peel polyphenol extract (APPE) with powerful antioxidant activity was evaluated under acidic conditions in vitro, and its protective effect against gastrointestinal damage was investigated in rats ...
-
Pastene, Edgar; Troncoso, Miriam; Figueroa, Guillermo; Alarcón, Julio; Speisky Cosoy, Hernán (2009)Apple peel extracts and their fractions pooled according to their molecular size were prepared and evaluated for their inhibitory activity against Helicobacter pylori and Jack bean ureases. Urease Inhibitory effect of apple ...
-
Jiménez T., Inés; Aracena Stiven, Paula; Letelier Muñoz, María Eugenia; Navarro, P.; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2002-04)Metallothionein (MT) and reduced glutathione (GSH) play an important role in the intracellular handling of copper by preventing the generation and favouring the removal of copper-derived free radicals. The present study ...
-
Cu(II)–disulfide complexes display simultaneous superoxide dismutase- and catalase-like activities Aliaga, Margarita E.; Andrade Acuña, Daniela; López Alarcón, Camilo; Sandoval Acuña, Cristián; Speisky Cosoy, Hernán (Elsevier, 2013)Superoxide is a potentially toxic by-product of cellular metabolism.We have addressed here the in vitro ability of complexes formed between copper(II) ions and various biologically-occurring disulfides (RSSR: oxidized ...
-
Espinoza, Mónica; Olea Azar, Claudio; Speisky Cosoy, Hernán; Rodríguez Borges, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2009-01)Four different types of Chilean wines (Cabernet Sauvignon, Merlot, Carmenere and Syrah) were selected and examined in their free radical scavenging capacities by electron spin resonance (ESR) and spectrophotometric methods. ...
-
Núñez Vergara, Luis; Yudelevich, J.; Squella Serrano, Juan; Speisky Cosoy, Hernán (Oxford University Press, 1991)Acetaldehyde, at concentrations occurring in vivo was found to avidly react in vitro with several clinically relevant drugs. The greatest reactivity was observed for the hydrazine and hydrazide-containing drugs, hydralazine ...
-
Loghin, Felicia; Chagraoui, Abdeslam; Asencio, Marcelo; Comoy, Etienne; Speisky Cosoy, Hernán; Cassels Niven, Bruce; Protais, Philippe (Elsevier Science B.V., 2002-11-20)(S)-(1)-boldine, an aporphine alkaloid displaying antioxidative and dopaminergic properties, and six of its derivatives (glaucine, 3-bromoboldine, 3-iodoboldine, 8-aminoboldine, 8-nitrosoboldine and 2,9-O,O9 -dipivaloylboldine) ...
-
Gotteland, Martín; Espinoza Madariaga, Julio; Cassels Niven, Bruce; Speisky Cosoy, Hernán (Sociedad Médica de Santiago, 1995-06-27)Boldo (Peumus boldus Molina) is a widely used medicinal planto However, its pbysiological effects are not well known. Recent studies in animals sbmoed tbat certain components o/ boldo relax smootb muscle and prolong ...
-
Fellenberg, M. A.; Delporte Vergara, Carla; Backhouse Erazo, Nadine; Peña, I.; Speisky Cosoy, Hernán (FACTA-FUNDACIO ARNCO CIENCIA TECNOLOGIA AVICOLAS, 2008-10)The addition of antioxidants to broiler diets has been shown to enhance their antioxidant status. Since boldo (Peumus boldus Mol.) leaves contain highly antioxidant molecules, a dried extract of boldo (DEB) was added to ...
-
Gironés Vilaplana, Amadeo; Baenas, Nieves; Villaño, Débora; Speisky Cosoy, Hernán; García Viguera, Cristina; Moreno, Diego A. (Elsevier, 2014)This work aimed to provide a thorough description of the polyphenolic composition of five Latin-American fruits of increasing interest, which have certain anti-diabetic effects (ac¸aı´, maqui, Cape gooseberry, papaya and ...
-
Sandoval Acuña, Cristián (Universidad de Chile, 2016)La mitocondria ha sido recientemente reconocida como potencial blanco molecular en el tratamiento del cáncer, dado que exhibe un potencial de transmembrana (Ψm) significativamente mayor en células tumorales que en células ...
-
Speisky Cosoy, Hernán; Gómez, Maritza; Burgos Bravo, Francesca; López Alarcón, Camilo; Jullian Matthaei, Carolina; Olea Azar, Claudio; Aliaga, Margarita E. (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03-01)The interaction between Cu2+ ions and GSH molecules leads to the swift formation of the physiologically occurring Cu(I)-[GSH](2) complex. Recently, we reported that this complex is able to reduce molecular oxygen into ...
-
Pastene, Edgar; Speisky Cosoy, Hernán; García, Apolinaria; Moreno, Jessica; Troncoso, Miriam; Figueroa, Guillermo (2010)The inhibitory effects of a standarized apple peel polyphenol-rich extract (APPE) against Helicobacter pylori infection and vacuolating bacterial toxin (VacA) induced vacuolation were investigated. Apple peel polyphenols ...
-
Pastene, Edgar; Speisky Cosoy, Hernán; Troncoso, Miriam; Alarcón, Julio; Figueroa, Guillermo (2009)In the present work, the in vitro effect of a standardized extract of apple peel APPE (60% of total polyphenols; 58% of flavonoids; 30% of flavan-3-ols and procyanidins) was evaluated with regard to the viability of ...
-
Sandoval Acuña, Cristian; López Alarcón, Camilo; Aliaga, Margarita E.; Speisky Cosoy, Hernán (2012)Mitochondrial dysfunction plays a major role in the development of oxidative stress and cytotoxicity induced by non-steroidal anti-inflammatory drugs (NSAIDs). A major objective of the present study was to investigate ...
-
Atala, E.; Velásquez Cisternas, Gonzalo; Vergara, C.; Mardones, C.; Reyes, J.; Tapia, R. A.; Quina, F.; Mendes, M. A.; Speisky Cosoy, Hernán; Lissi, E.; Ureta Zañartu, M. S.; Aspée, A.; López Alarcón, C. (2013)Pyrogallol red (PGR) presents high reactivity toward reactive (radical and nonradical) species (RS). This property of PGR, together with its characteristic spectroscopic absorption in the visible region, has allowed ...